Radial diffusivity predicts demyelination in ex vivo multiple sclerosis spinal cords
نویسندگان
چکیده
منابع مشابه
Radial diffusivity predicts demyelination in ex vivo multiple sclerosis spinal cords
OBJECTIVE Correlation of diffusion tensor imaging (DTI) with histochemical staining for demyelination and axonal damage in multiple sclerosis (MS) ex vivo human cervical spinal cords. BACKGROUND In MS, demyelination, axonal degeneration, and inflammation contribute to disease pathogenesis to variable degrees. Based upon in vivo animal studies with acute injury and histopathologic correlation,...
متن کاملRecovery after spinal cord relapse in multiple sclerosis is predicted by radial diffusivity
BACKGROUND The aim of this study was to determine whether the diffusion tensor-derived radial diffusivity and axial diffusivity, measured in the cortico-spinal tract in the cervical cord, predict clinical recovery after a cord relapse in patients with multiple sclerosis, and change over time. METHODS Fourteen patients were clinically assessed at the onset of a cervical cord relapse and after ...
متن کاملDemyelination versus remyelination in progressive multiple sclerosis.
The causes of incomplete remyelination in progressive multiple sclerosis are unknown, as are the pathological correlates of the different clinical characteristics of patients with primary and secondary progressive disease. We analysed brains and spinal cords from 51 patients with progressive multiple sclerosis by planimetry. Thirteen patients with primary progressive disease were compared with ...
متن کاملInflammatory cortical demyelination in early multiple sclerosis.
BACKGROUND Cortical disease has emerged as a critical aspect of the pathogenesis of multiple sclerosis, being associated with disease progression and cognitive impairment. Most studies of cortical lesions have focused on autopsy findings in patients with long-standing, chronic, progressive multiple sclerosis, and the noninflammatory nature of these lesions has been emphasized. Magnetic resonanc...
متن کاملExtensive hippocampal demyelination in multiple sclerosis.
Memory impairment is especially prominent within the spectrum of cognitive deficits in multiple sclerosis (MS), and a crucial role for hippocampal pathology may therefore be expected in this disease. This study is the first to systematically assess hippocampal demyelination in MS. Hippocampal tissue samples of 19 chronic MS cases and 7 controls with non-neurologic disease were stained immunohis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: NeuroImage
سال: 2011
ISSN: 1053-8119
DOI: 10.1016/j.neuroimage.2011.01.007